- Capability group
- Biotechnology & Health Technologies
- Domain
- Critical Technology · Hard Power
- Identifier
- factbase.org/cap/SXV2R9FW2K
- Reference
- Biomanufacturing Wikipedia
Papers
2.4k
2020–2024
Paper growth
+42%
2020–24 on 2015–19
Patent families
126.5k
2020–2024
Filed abroad
30%
families in more than one office
What it covers
What the capability covers and what it leaves to others, and the indicators it will be measured by.
Bounds
Covers biomanufacturing technology and capacity; the plants belong to Strategic Infrastructure, product markets to the economic domains, and sovereign production of countermeasures reads at this capability's make layer with the products under the therapeutics capability.
Lineage
Carried from v0.0 (formerly Biological manufacturing) with the same identifier; recast from a definition of biomanufacturing to the sovereign production capacity, the layer at which states now deliberately build.
Indicators
- biologics manufacturing capacityPending
- vaccine production capacityPending
- fermentation capacity installedPending
Who publishes it
Papers classified to the capability, by year and by the nation of their authors' institutions, 2020–2024. Read from the v0.0 research topic Biological manufacturing.
Papers by year
The five leading nations, papers by year
Share of papers, 2020–2024
Of papers with a known author nation; 31% have none and are left out.
- 1China14.4%306 papers
- 2India12.4%264 papers
- 3United States12.1%259 papers
- 4Germany3.8%82 papers
- 5South Korea3.7%78 papers
- 6United Kingdom3.4%72 papers
- 7Brazil3.0%65 papers
- 8Australia2.4%52 papers
- 9Italy2.3%49 papers
- 10Spain2.3%49 papers
Leading institutions, 2020–2024
By fractional count: each paper divided among its authors' institutions.
- 1Chinese Academy of Sciences9fractional papers
- 2Vellore Institute of Technology University6fractional papers
- 3Shanghai Jiao Tong University6fractional papers
- 4Zhejiang University5fractional papers
- 5Purdue University West Lafayette5fractional papers
- 6Tufts University4fractional papers
- 7University College London4fractional papers
- 8Zhengzhou University3fractional papers
- 9University of Chinese Academy of Sciences3fractional papers
- 10Universidad Politécnica de Madrid3fractional papers
Who patents it
Patent families by the nation of origin of their applicants and their earliest priority year, from the CPC and IPC classes the capability is read from. 2025 onwards is incomplete: families are published 18 months after priority.
Families by priority year
The five leading origins, families by year
53,073 applicants filed here in 2015–2024; the five largest held 2% of families (HHI 3 of 10,000: unconcentrated).
Share of families by origin, 2020–2024
- 1China66.6%84,298 families
- 2United States11.4%14,407 families
- 3Japan6.0%7,552 families
- 4South Korea5.4%6,893 families
- 5Germany1.5%1,903 families
- 6France0.9%1,138 families
- 7United Kingdom0.9%1,104 families
- 8Taiwan0.7%868 families
- 9Switzerland0.6%802 families
- 10Canada0.6%707 families
Applicants filing most internationally, 2015–2024
Families filed in more than one office, by applicant as the offices name them.
- 1UNIV CALIFORNIA975international families
- 2CJ CHEILJEDANG CORP564international families
- 3PIONEER HI BRED INT526international families
- 4HOFFMANN LA ROCHE453international families
- 5CENTRE NAT RECH SCIENT447international families
- 6INST NAT SANTE RECH MED389international families
- 7FUJIFILM CORP384international families
- 8HARVARD COLLEGE367international families
- 9UNIV LELAND STANFORD JUNIOR354international families
- 10UNIV KYOTO327international families
Classification read
- C12P Fermentation and enzyme processes for making compounds · 844.2k documents
- C12M Bioreactors, fermenters and cell-culture apparatus · 787.5k documents
- C12N5/00 Cell lines and cell culture · 584.5k documents
- C12N7/00 Viruses and viral vectors: preparation and purification · 127.2k documents
- C07K1/14 Protein extraction and purification · 103.4k documents
Shares inventions with
Capabilities whose classes the same families also fall in, by overlap (Jaccard).
- Synthetic Biology & Genetic Engineering31,960 families · 0.282
- Advanced Therapeutics, Vaccines & Medical Countermeasures24,652 families · 0.201
- Genomics & Biological Data8,295 families · 0.081
Who makes it
The companies that research, design, make, supply and operate the technology, the global leaders and the leading firms of every region.
50 companies in this capability, from 22 nations across 8 regions. Sorted by how experts see each company's global relevance in the field, from very high to very low.
- Very high5 companies
- 1Very highEquipment & machineryWalthamUnited States1956125kTMO
Largest supplier of bioprocess media, single-use systems and analytics, and through Patheon one of the largest biologics and viral-vector CDMOs.
Very high relevance · Equipment & machinery · United States, Waltham · founded 1956 · 125k staff
- 2Very highEquipment & machineryWashington, D.C.United States196963kDHR
Its Cytiva and Pall units are the leading suppliers of chromatography resins, filtration, bioreactors and turnkey modular biologics plants (KUBio).
Very high relevance · Equipment & machinery · United States, Washington, D.C. · founded 1969 · 63k staff
- 3Very highContract manufacturingBaselSwitzerland189718kLONN
World's largest contract development and manufacturing organisation for biologics, cell and gene therapies, with mammalian and microbial capacity across Europe, US and Asia.
Very high relevance · Contract manufacturing · Switzerland, Basel · founded 1897 · 18k staff
- 4Very highContract manufacturingIncheonSouth Korea2011–207940
Operates the world's largest single-site biologics manufacturing capacity at Songdo (over 780,000 L across Plants 1-5).
Very high relevance · Contract manufacturing · South Korea, Incheon · founded 2011
- 5Very highEquipment & machineryGöttingenGermany1870–SRT3
Sartorius Stedim Biotech is a leading maker of single-use bioreactors, filters, fluid management and cell culture media for biologics production.
Very high relevance · Equipment & machinery · Germany, Göttingen · founded 1870
- High10 companies
- 6HighContract manufacturingWuxiChina2010–2269
China's leading biologics CDMO with large single-use bioreactor networks in China, Ireland and Germany serving global drug developers.
High relevance · Contract manufacturing · China, Wuxi · founded 2010
- 7HighChemicals & gasesTokyoJapan1934–4901
Fujifilm (Fujifilm Diosynth Biotechnologies)Fujifilm Diosynth is a top-tier biologics CDMO building very large mammalian cell culture plants in Denmark and Holly Springs, North Carolina.
High relevance · Chemicals & gases · Japan, Tokyo · founded 1934
- 8HighChemicals & gasesDarmstadtGermany166863kMRK
Its Life Science sector (MilliporeSigma) supplies filtration, chromatography, media and contract viral-vector and ADC manufacturing to the bioprocess industry.
High relevance · Chemicals & gases · Germany, Darmstadt · founded 1668 · 63k staff
- 9HighChemicals & gasesMelbourneAustralia1916–CSL
Runs one of the world's largest plasma-fractionation networks (CSL Behring) and, through CSL Seqirus, cell-based and egg-based influenza vaccine plants.
High relevance · Chemicals & gases · Australia, Melbourne · founded 1916
- 10HighChemicals & gasesBagsværdDenmark2024–NSIS B
Formed by merging Novozymes and Chr. Hansen, it is the world's largest industrial enzyme and microbial culture producer with vast fermentation capacity.
High relevance · Chemicals & gases · Denmark, Bagsværd · founded 2024
- 11HighMedicines & vaccinesPuneIndia1966–Private
World's largest vaccine manufacturer by doses, producing over 1.5 billion doses a year including measles, polio, HPV and malaria (R21) vaccines.
High relevance · Medicines & vaccines · India, Pune · founded 1966
- 12HighMedicines & vaccinesIngelheim am RheinGermany1885–Private
Boehringer Ingelheim (BioXcellence)Operates large in-house and contract (BioXcellence) biopharmaceutical production in Biberach, Vienna and Fremont, one of Europe's biggest biologics capacities.
High relevance · Medicines & vaccines · Germany, Ingelheim am Rhein · founded 1885
- 13HighContract manufacturingSomerset, New JerseyUnited States2007–Private
Major biologics and gene-therapy CDMO, acquired by Novo Holdings in December 2024 with three fill-finish sites transferred to Novo Nordisk.
High relevance · Contract manufacturing · United States, Somerset, New Jersey · founded 2007
- 14HighChemicals & gasesSeoulSouth Korea1953–097950
World's largest producer of fermented amino acids (lysine, methionine, tryptophan) and a PHA biopolymer maker, and a top patent filer in microbial production strains.
High relevance · Chemicals & gases · South Korea, Seoul · founded 1953
- 15HighMedicines & vaccinesParisFrance197383kSAN
One of the largest vaccine producers globally and builder of modular 'Evolutive' biomanufacturing facilities in France and Singapore.
High relevance · Medicines & vaccines · France, Paris · founded 1973 · 83k staff
- Moderate17 companies
- 16ModerateChemicals & gasesKaiseraugstSwitzerland2023–DSFIR
Large-scale fermentation producer of vitamins, enzymes, cultures, omega-3 algal oils and biotech ingredients.
Moderate relevance · Chemicals & gases · Switzerland, Kaiseraugst · founded 2023
- 17ModerateChemicals & gasesTokyoJapan1909–2802
Pioneer of industrial amino-acid fermentation and, through Ajinomoto Bio-Pharma Services, a CDMO for biologics and oligonucleotides.
Moderate relevance · Chemicals & gases · Japan, Tokyo · founded 1909
- 18ModerateChemicals & gasesMinnetonka, MinnesotaUnited States1865160kPrivate
Operates large industrial fermentation for bio-based ingredients, sweeteners (EverSweet) and lactic acid, and co-owns NatureWorks, the largest PLA producer.
Moderate relevance · Chemicals & gases · United States, Minnetonka, Minnesota · founded 1865 · 160k staff
- 19ModerateChemicals & gasesChicagoUnited States1902–ADM
Runs some of the largest corn-based fermentation complexes in the world (Decatur) for ethanol, amino acids, organic acids and precision-fermentation contract production.
Moderate relevance · Chemicals & gases · United States, Chicago · founded 1902
- 20ModerateMedicines & vaccinesIncheonSouth Korea2002–068270
Leading biosimilar developer with large mammalian cell-culture manufacturing plants in Songdo.
Moderate relevance · Medicines & vaccines · South Korea, Incheon · founded 2002
- 21ModerateProfessional & data servicesBostonUnited States2008–DNA
Cell-programming foundry that designs and scales microbial and mammalian production strains for pharma, agriculture and industrial customers.
Moderate relevance · Professional & data services · United States, Boston · founded 2008
- 22ModerateChemicals & gasesWaltham, MassachusettsUnited States1981–RGEN
Specialist supplier of Protein A ligands, tangential-flow filtration, perfusion (XCell ATF) and chromatography columns for bioprocessing.
Moderate relevance · Chemicals & gases · United States, Waltham, Massachusetts · founded 1981
- 23ModerateAdvanced materialsTokyoJapan1907–5201
AGC Biologics, headquartered in Bothell, Washington, is a global CDMO for mammalian and microbial proteins, plasmid DNA, mRNA and viral vectors.
Moderate relevance · Advanced materials · Japan, Tokyo · founded 1907
- 24ModerateMedicines & vaccinesCambridge, MassachusettsUnited States20105,800MRNA
Built the first commercial-scale mRNA vaccine manufacturing and is establishing sovereign mRNA plants in Canada, the UK and Australia.
Moderate relevance · Medicines & vaccines · United States, Cambridge, Massachusetts · founded 2010 · 5,800 staff
- 25ModerateMedicines & vaccinesBeijingChina1998–State-owned
Sinopharm (China National Biotec Group)State group whose CNBG subsidiary is China's largest vaccine and blood-products manufacturer and produced billions of COVID-19 vaccine doses.
Moderate relevance · Medicines & vaccines · China, Beijing · founded 1998
- 26ModerateMedicines & vaccinesBengaluruIndia1978–BIOCON
India's largest biopharmaceutical maker, producing insulins and monoclonal-antibody biosimilars via Biocon Biologics in Bengaluru and Malaysia.
Moderate relevance · Medicines & vaccines · India, Bengaluru · founded 1978
- 27ModerateChemicals & gasesEssenGermany200732kEVK
Produces fermentation-based amino acids, rhamnolipid biosurfactants and lipid nanoparticle materials for mRNA biomanufacturing.
Moderate relevance · Chemicals & gases · Germany, Essen · founded 2007 · 32k staff
- 28ModerateChemicals & gasesLangfangChina––600873
One of the world's largest amino-acid and glutamate fermentation producers, operating huge fermentation complexes in Inner Mongolia and Xinjiang.
Moderate relevance · Chemicals & gases · China, Langfang
- 29ModerateChemicals & gasesAmsterdamNetherlands1919–CRBN
Global leader in fermentation-derived lactic acid and lactides and producer of algae-based omega-3.
Moderate relevance · Chemicals & gases · Netherlands, Amsterdam · founded 1919
- 30ModerateContract manufacturingOxfordUnited Kingdom1995–OXB
Leading lentiviral and AAV vector CDMO that manufactured the Oxford-AstraZeneca vaccine and supplies vectors for CAR-T therapies.
Moderate relevance · Contract manufacturing · United Kingdom, Oxford · founded 1995
- 31ModerateMedicines & vaccinesHyderabadIndia1996–Private
Major vaccine manufacturer producing Covaxin, rotavirus and typhoid conjugate vaccines with BSL-3 production capacity.
Moderate relevance · Medicines & vaccines · India, Hyderabad · founded 1996
- 32ModerateMedicines & vaccinesHyderabadIndia1953–Private
Large WHO-prequalified vaccine maker (Corbevax, PCV, pentavalent) and contract manufacturer for global vaccine programmes.
Moderate relevance · Medicines & vaccines · India, Hyderabad · founded 1953
- Low13 companies
- 33LowChemicals & gasesShanghaiChina1997–688065
World-leading producer of bio-based long-chain dibasic acids and bio-pentanediamine (bio-polyamide) via industrial fermentation.
Low relevance · Chemicals & gases · China, Shanghai · founded 1997
- 34LowResearch & IPSkokieUnited States2005–LNZA
Commercialised gas-fermentation technology converting industrial off-gases to ethanol at plants in China, Belgium and India.
Low relevance · Research & IP · United States, Skokie · founded 2005
- 35LowMedicines & vaccinesSeongnamSouth Korea2018–302440
Korea's leading vaccine manufacturer with the Andong L House plant, which produced Novavax and AstraZeneca COVID vaccines and its own SKYCovione.
Low relevance · Medicines & vaccines · South Korea, Seongnam · founded 2018
- 36LowResearch & IPBengaluruIndia1993–SYNGENE
Indian CRDMO with biologics manufacturing in Bengaluru and a biologics plant acquired from Emergent in Baltimore.
Low relevance · Research & IP · India, Bengaluru · founded 1993
- 37LowContract manufacturingSan DiegoUnited States2020––
Venture-backed biomanufacturing network building advanced production capacity for biologics, vaccines and cell and gene therapies in the US and Canada.
Low relevance · Contract manufacturing · United States, San Diego · founded 2020
- 38LowContract manufacturingTaipeiTaiwan2012–6589
Taiwan's leading biologics CDMO and biosimilar developer with microbial and mammalian GMP plants in Hsinchu.
Low relevance · Contract manufacturing · Taiwan, Taipei · founded 2012
- 39LowContract manufacturingCharlottetownCanada1970–Private
Canadian CDMO for microbial fermentation, mRNA and lipid components that received federal funding to expand domestic biomanufacturing.
Low relevance · Contract manufacturing · Canada, Charlottetown · founded 1970
- 40LowMedicines & vaccinesBandungIndonesia1890–State-owned
Southeast Asia's largest vaccine maker, a WHO-prequalified supplier of polio and other vaccines to over 140 countries.
Low relevance · Medicines & vaccines · Indonesia, Bandung · founded 1890
- 41LowMedicines & vaccinesDurbanSouth Africa1850–APN
Africa's largest pharmaceutical manufacturer, whose Gqeberha sterile plant filled J&J COVID vaccines and is licensed to make Aspenovax.
Low relevance · Medicines & vaccines · South Africa, Durban · founded 1850
- 42LowChemicals & gasesRio de JaneiroBrazil2011–RAIZ4
Brazil's largest sugarcane ethanol fermenter and operator of commercial second-generation cellulosic ethanol plants.
Low relevance · Chemicals & gases · Brazil, Rio de Janeiro · founded 2011
- 43LowMedicines & vaccinesRio de JaneiroBrazil1976–State-owned
Fiocruz's immunobiologicals institute, Latin America's largest vaccine producer and a WHO-prequalified yellow fever vaccine supplier, also part of the mRNA hub network.
Low relevance · Medicines & vaccines · Brazil, Rio de Janeiro · founded 1976
- 44LowContract manufacturingGdańskPoland––Private
Central and Eastern Europe's main biosimilar and biologics CDMO with mammalian and microbial plants in Gdańsk, Warsaw and Utrecht.
Low relevance · Contract manufacturing · Poland, Gdańsk
- 45LowResearch & IPBudapestHungary1901–RICHTER
Operates a large mammalian and microbial biologics manufacturing site in Debrecen producing biosimilars such as denosumab and teriparatide.
Low relevance · Research & IP · Hungary, Budapest · founded 1901
- Very low5 companies
- 46Very lowContract manufacturingCape TownSouth Africa2003–Private
South African vaccine manufacturer developing end-to-end production (oral cholera vaccine, Pfizer COVID fill-finish) and an mRNA hub partner.
Very low relevance · Contract manufacturing · South Africa, Cape Town · founded 2003
- 47Very lowResearch & IPCape TownSouth Africa2014––
Hosts the WHO mRNA technology transfer hub, developing mRNA vaccine manufacturing processes for transfer to producers in low and middle-income countries.
Very low relevance · Research & IP · South Africa, Cape Town · founded 2014
- 48Very lowMedicines & vaccinesCairoEgypt––State-owned
Egypt's state Holding Company for Biological Products and Vaccines, producing sera and vaccines and locally manufacturing Sinovac COVID vaccine.
Very low relevance · Medicines & vaccines · Egypt, Cairo
- 49Very lowOperations & infrastructureAbu DhabiUnited Arab Emirates2018–Private
G42-Sinopharm joint venture that built the UAE's first vaccine manufacturing plant at KEZAD producing Hayat-Vax.
Very low relevance · Operations & infrastructure · United Arab Emirates, Abu Dhabi · founded 2018
- 50Very lowMedicines & vaccinesGarínArgentina2009–Private
Argentine vaccine and biologics maker producing influenza and HPV vaccines and selected by WHO/PAHO as a Latin American mRNA vaccine development centre.
Very low relevance · Medicines & vaccines · Argentina, Garín · founded 2009
